These pathways contained 10 common genes, i.e., LDLR, LPA, PLG, APOE, LIPA, LPL, APOB, ABCG8, ABCG5, APOC4 (Additional file 2: Table S4), that were significantly associated with CAD (P < 2.72 × 10− 06) by using the MAGMA analysis. This evidence concerns the gene LDLR and coronary artery disorder.