The function of NK cells against tumor cells is through various mechanisms including releasing cytoplasmic granules (such as Perforin and Granzyme), secretion of various cytokines (such as IFN-γ and TNF-α), triggering death receptor-mediated apoptosis (such as FasL or TRAIL), ADCC by CD16 antigen expression on the NK cells, and also indirectly via interaction with other immune cells (Cheng et al., 2013). This evidence concerns the gene TNF and neoplasm.