PROS1 and cancer: This explains the powerful binding of KPT-330 in slowly reversible action with XPO1 leading to inhibition the binding between the cargoes proteins and XPO1 in HT29 cancer cell line which in turn induce nuclear retention of cell cycle regulatory proteins, inhibits the proliferation and may initiate the apoptosis (Draetta et al., 2011; Senapedis et al., 2014).