XPO1 and lung cancer: In some tumors such as lung cancer and mantle cell lymphoma cells, the XPO1 inhibitors modulate the NF-κB activity through trapping of IκB in the nucleus, which is target of XPO1 for nucleocytoplasmic transportation, leading to repression of NF-κB activity over time which contributes in the growth suppression and apoptosis induction (Zhang et al., 2013).