TP53 and neoplasm: In this regard, we identified that the overexpression of XPO1 was strongly associated with Ki67 expression, which in turn reflected the implication of XPO1 overexpression in mislocalization of essential cell cycle inhibitory proteins such as p27, p53, cyclins and some apoptotic proteins (Nguyen et al., 2012; Niu et al., 2015) lead to unregulated cell division and increased tumor size.