In the current study, we noticed a significant apparent of XPO1 overexpression in CRC tumor cells compared to the adjacent normal epithelium as it was reported in many other types of cancers such as esophageal (van der Watt et al., 2014), gastric (Subhash et al., 2018), lung (Gao et al., 2015), and ovarian (Noske et al., 2008) cancers, as well as leukemic cells (Kojima et al., 2013). The gene discussed is XPO1; the disease is colorectal carcinoma.