On the same manner, the CRC tumors sizes in this study ranges from 3 to 11 cm with mean 6.6 cm and we noted that the high nuclear Ki67 expression was associated with an increase tumor size (P=0.012) but not XPO1 (P=0.168), with Mann-Whitney test, as it is illustrated in Figure 3. Here, XPO1 is linked to neoplasm.