MMP9 and neoplasm: On the other hand, it has been proved that the activated NF-κB contributes in the progression of CRC through upregulation expression of diverse target genes that are involved in inflammation (cytokines), cell proliferation (Cyclin D1), angiogenesis (VEGF, IL-8, COX2), and metastasis (MMP9) (Wang et al., 2009; Xie et al., 2019) make it an interesting tumor marker in CRC pathogenesis.