In CRC, little is known about the overexpression of XPO1 in tissue samples and its association with histopathological features, NF-κB and Ki67. Our previous study concerned of p53, reported that the XPO1 positivity was associated with loss of p53 expression in CRC tumors with lymph node metastasis (Aladhraei et al., 2019). The gene discussed is MKI67; the disease is colorectal carcinoma.