Moreover, Triple negative breast cancer (TNBC), characterized by the lacks of expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor2 (HER2) (Lukoseviciene et al., 2018), is the most aggressive among the subtype of breast cancer and represents about 15% of all case of breast cancer (Millikan et al., 2008; Yang et al., 2019; Abramson et al., 2015; Wen et al., 2019). Here, ESR1 is linked to breast cancer.