A single-pass typeII membrane protein transmembrane protease serine4 (TMPRSS4) is a novel serine protease discovered at the cell surface. TMPRSS4 is highly expressed in several types of cancer cell lines (Chikaishi et al., 2016; Wu et al., 2014; Liang et al., 2013) especially the TNBC cell line (Cheng et al., 2013; Li et al., 2017). TMPRSS4 is also implicated in cancer cell proliferation (Huang et al., 2014; Kim et al., 2010) and cancer radiotherapy (Li et al., 2011). This evidence concerns the gene TMPRSS4 and cancer.