which is not been profoundly seen in other populations studied; In Breast cancers, authors found very low percentage of mutations in BRCA1 gene but much higher percentages in TP53 gene (Hussain et al., 2009),Similarly we have a unique cancer called Kangri cancer of Skin where we showed different mutational spectrum in TP53 and PTEN genes as compared to other skin cancers. The gene discussed is PTEN; the disease is skin cancer.