which is not been profoundly seen in other populations studied; In Breast cancers, authors found very low percentage of mutations in BRCA1 gene but much higher percentages in TP53 gene (Hussain et al., 2009),Similarly we have a unique cancer called Kangri cancer of Skin where we showed different mutational spectrum in TP53 and PTEN genes as compared to other skin cancers. This evidence concerns the gene TP53 and breast carcinoma.