In a univariate Cox regression analysis of the factors predictive of OS and PFS in patients with EGFR-mutation-positive NSCLC treated with EGFR-TKI, IHC-detected BIM expression was the only predictive factor for both mOS (HR=1.66, 95% CI=1.010122.72, P 0.04) and mPFS (HR=1.69, 95% CI=1.12–2.55, P=0.01) (Table 6). Here, EGFR is linked to non-small cell lung carcinoma.