A common intronic deletion polymorphism in the gene encoding BIM has been described in which BIM splicing is switched from exon 4 to exon 3 resulting BIM isoforms lack pro-apoptotic BH3 activity causing resistant of EGFR TKIs in NSCLC cell line (Ng et al., 2012). This evidence concerns the gene BCL2L11 and non-small cell lung carcinoma.