PDPN and neoplasm: The immunohistochemical factors of lymphatic endothelial cells, such as D2-40 (podoplanin), lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE1), and VEGF receptor-3 (VEGFR-3), indicate the lymphatic vessel count (Zolfaghari Saravi et al, 2017) associated with the tumor which can metastasize to lymph nodes (Miller, 2005).