The three SNPs involved in the most significant interactions were TMEM173 rs13153461, which also associated with CRC risk as a single SNP, the TMEM173 eQTL SNP rs7380272, and the IKBKE 5ʹUTR SNP rs2297549. Interestingly, TMEM173 rs13153461 and TMEM173 rs7380272 show a moderate LD (r2 = .38), indicating that some of the interactions may be due to a modest LD between the SNPs. This evidence concerns the gene STING1 and colorectal carcinoma.