On the other hand, an increased and decreased risk of CRC was observed when IKBKE rs15672 (minor allele homozygote genotype) interacted with TMEM173 rs13153461 (minor allele homozygote genotype) and TMEM173 rs7380272 (major allele homozygote genotype), respectively (Table S4). This evidence concerns the gene IKBKE and colorectal carcinoma.