Recent studies have shown that the cGAS‐STING and TLR3 pathways, which through the TBK1‐IKKε phosphorylation induce the type I IFNs production, are disturbed in CRC, mainly because of an imbalanced expression of their coding genes.20, 29 cGAS produces cGAMP in response to cytosolic DNA, which in turn can bind and activate STING.30 It has been described that the levels of 2ʹ, 3ʹ ‐cGAMP, or its analogs are important for the immune system to decide which direction to follow. This evidence concerns the gene IKBKE and colorectal carcinoma.