XPC and colorectal carcinoma: So far, genome‐wide association studies have reported ~100 risk loci for CRC highlighting new genes and pathways contributing to CRC susceptibility and suggesting roles for Hedgehog signaling, Krüppel‐like factors, Hippo‐YAP signaling, and immune function.4, 5 Hua et al have also suggested that polymorphisms within xeroderma pigmentosum group C (XPC) and G (XPG) genes may affect CRC susceptibility through impairment of the nucleotide excision repair (NER) pathway.6, 7