As our in vitro data suggested that prolonged activation of anti‐oxidant pathways and HO‐1 activity induced ferritin, likely due to iron release, we investigated ferritin and other markers of iron metabolism in resected epileptogenic brain tissue of patients with FCD IIb, TSC as well as in Tsc1GFAP−/− mice. This evidence concerns the gene HMOX1 and fleck corneal dystrophy.