To prove the presence of OS damage and activation of Nrf‐2 signalling in the epileptogenic pathologies FCD IIb and TSC, we assessed the expression of the OS damage marker 4‐hydroxynonenal (4‐HNE), the DNA damage marker phosphorylated H2A histone family member X (γH2A.X), as well as the expression of Nrf‐2 and HO‐1. This evidence concerns the gene HMOX1 and tuberous sclerosis.