Since the peak serum activity of SDH in individual woodchucks was temporally associated with the maximum expression of T-cell markers and cytolytic effector molecules, as well as with the marked decline in WHV replication, peak WHV-specific T-cell responses (see Fig 1), pronounced hepatitis/liver inflammation, and increased replenishment of liver with hepatocytes (Table 1), this may indicate the presence of a cytolytic mechanism of viral clearance by mainly CTLs. The gene discussed is SORD; the disease is Hepatitis.