NFKB1 and bacterial infectious disease: Many biological factors (e.g. inflammatory cytokines), oxidative stress, external stimuli (e.g. bacterial infections and gamma-radiation) or pathophysiological conditions (e.g ischemia) have been associated with activation of NF-κB supporting its role for elaboration of plenty signaling pathways that regulate the different biological functions [27]. The translocation of NF-κB into the nucleus in turn regulates the expression of other pro-inflammatory cytokines, growth factors, and differentiation-regulating mediators, the signals mandatory for wound healing.