Further analysis revealed that AML1-ETO increases expression of genes that regulate blood coagulation and angiogenesis (cluster 4) such as PDGFA, PDGFB and several platelet glycoproteins, processes that are frequently targeted in leukemia to promote proliferation of blast cells and to increase bone marrow vasculature for survival of leukemia [26–29]. Here, RUNX1 is linked to leukemia.