Neutrophil granules contain products (myeloperoxidase, elastase, lactoferrin, hydrolases, complement activators) that possess not only microbicidal but also have highly cytotoxic effects.[13, 14] Increased azurophilic granule activity has not yet been confirmed directly in neutrophils from patients with SCD although high plasma circulating levels of elastase and lactoferrin have been measured, suggesting increased product release from the neutrophil stores.[15]. This evidence concerns the gene MPO and Schnyder corneal dystrophy.