While the coronal but not lambdoid suture is affected in humans and mouse models of Saethre-Chotzen syndrome, in which TWIST1 and TCF12 mutations are heterozygous, only homozygous loss of both twist1b and tcf12 disrupts the zebrafish ‘coronal’ (i.e. lambdoid homolog), potentially consistent with greater sensitivity of the coronal than lambdoid to TWIST1/TCF12 disruption. The gene discussed is TCF12; the disease is Saethre-Chotzen syndrome.