Numerous studies show that the proteins associated with neurodegenerative disorders such as Alzheimer’s disease (Aβ 6 and tau 7, 8), Parkinson’s and multiple system atrophy (α‐synuclein 9, 10), frontotemporal dementia (TDP43 11, tau 12, 13, 14 or FUS 15) and motor neurone disease (TDP43 11), exhibit at least some of the properties of abnormal prion protein 16 (the first reports of the misfolded protein presence in respective diseases are referenced here and also shown in Figure 1). This evidence concerns the gene TARDBP and early-onset autosomal dominant Alzheimer disease.