CACNA1C and bipolar disorder: Genome-wide association studies (GWAS) of patients with bipolar disorder, schizophrenia and autism spectrum disorders (ASD) have identified gain- and loss-of-function mutations in CACNA1C, the gene encoding the α1C subunit of the voltage-gated L-type calcium channel (LTC) Cav1.2 (Ferreira et al., 2008; Green et al., 2010; Ripke et al., 2013).