STAT3 and glioma: Additionally, STAT3 is widely known to be aberrantly up‐regulated in the progression of cancer.28 In line with the observations of the current study, accumulating reports have reported the up‐regulation of STAT3 in GBM stem cells and glioma.29, 30 Furthermore, it has been reported previously that STAT3 activation up‐regulates TRIM8 in order to regulate the stemness in GBM cells.31