Down‐regulated STAT3 has been reported to effectively enhance autophagy as well as the apoptosis of GBM cells in orthotopic transplanted rat samples, while blockade of the STAT3 signaling pathway may also trigger the apoptosis of glioma cells.18, 19 The upstream regulatory miRNAs of STAT3 were explored by the bioinformatics websites. The gene discussed is STAT3; the disease is central nervous system cancer.