The let‐7 family is generally considered to be a cancer suppressor which has been evidenced by its distinct down‐regulation in a variety of tumors.11, 20, 21, 22 Taken together, miR cluster MC‐let‐7a‐1 ~ let‐7d may have the potential to regulate glioma cell autophagy and apoptosis by targeting STAT3 in glioma. This evidence concerns the gene STAT3 and central nervous system cancer.