In addition, the apoptosis of the glioma cells as well as the ratio of c‐Caspase‐3/t‐Caspase‐3 was increased, whereas the protein expression of Bcl‐2 was diminished as indicated by the flow cytometry results which demonstrated that the expression of the apoptosis‐related proteins after down‐regulation of STAT3 (Figure 8B,C). The gene discussed is STAT3; the disease is central nervous system cancer.