It has been demonstrated that overexpression of NICD3 can transactivate oestrogen receptor (ER) α (ERα) in breast cancer cells through binding at RBP-Jκ responsive binding elements in the ERα promoter [122] and Notch1 can induce ERα-dependent transcription via IKKα-dependent recruitment of Notch transcriptional complexes [26]. The gene discussed is NOTCH1; the disease is breast carcinoma.