We have shown that significant differences in the expression of ESRP1, TGF-β1 and bFGF were indicated in bleomycin-induced pulmonary fibrosis, and apparent EMT signs were detected in siESRP1 cells that were treated with TGF-β1, bFGF and bleomycin. The gene discussed is TGFB1; the disease is pulmonary fibrosis.