To date, two genetic disorders caused by mutations in SMC5/6 have been reported: the NSMCE2‐associated syndrome featuring primordial dwarfism and deregulation of glucose metabolism 16, and the NSMCE3‐associated disorder also known as LICS, characterized by increased chromosome breakage and defective T‐ and B‐cell function 17. This evidence concerns the gene SMC5 and hereditary disease.