Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive degeneration of lower motor neurons, as well as neurons in the cortex and brainstem, which leads to paralysis and premature death.1 The etiology of ALS remains unclear both in sporadic cases (90%) and in the familial forms of ALS.1, 2 Among the known genetic causes that give rise to ALS, the mutation of the fused in sarcoma protein (FUS) is the second most frequent among the familial forms of ALS.2, 3, 4. This evidence concerns the gene FUS and amyotrophic lateral sclerosis.