To clarify the role of Nedd4 and Nedd4l in intestinal tumorigenesis, we further crossed the mutant mice to Apcmin animals, a mouse model of colon cancer (Su et al, 1992), to obtain Apcmin Nedd4 cKO, Apcmin Nedd4l cKO, and the compound Apcmin DKO mice. Here, NEDD4 is linked to colonic neoplasm.