Previous studies have identified several crypt‐expressing Wnt inhibitors such as AXIN2, RNF43 and SH3BP4 that are involved in CRC development by targeting Wnt signalling pathway at different subcellular levels (Cancer Genome Atlas, 2012; Giannakis et al, 2014, Yan et al, 2017a; Antas et al, 2019). The gene discussed is RNF43; the disease is colorectal carcinoma.