NEDD4 has been reported as a tumour suppressor (March et al, 2011; Zeng et al, 2014; Lu et al, 2016), while others have suggested that NEDD4 is a proto‐oncogene by targeting the tumour suppressor PTEN for degradation (Kim et al, 2008; Eide et al, 2013). This evidence concerns the gene NEDD4 and neoplasm.