By contrast, COX‐2 is an inducible enzyme responsible for the production of prostaglandins at sites of inflammation and wound‐healing.25 Of note, COX‐2 is highly expressed in numerous types of human cancer, such as breast, ovarian, colorectal cancer, and NPC.26, 27, 28, 29 Our previous studies reported that COX‐2 serves as a marker of poor prognosis in NPC, and COX‐2 expression induces proliferation and chemoresistance of NPC cells.30 However, stromal expression of COX‐2 has not been specifically evaluated in NPC to date. The gene discussed is PTGS2; the disease is cancer.