Of these, only A2AR (encoded by the ADORA2A gene) was highly expressed in mouse and human C/EBPα-mutated cells.[43] A2AR affects immune processes including pro-inflammatory cytokine secretion, macrophage-mediated phagocytosis, and C2 activation.[44] In the context of CEBPA-mutated AML, adenosine signaling appears to function in a paracrine or autocrine manner through A2AR, as A2AR inhibition showed beneficial effects in a mouse model of CEBPA-mutated AML. This evidence concerns the gene ADORA2A and acute myeloid leukemia.