A very recent observation with functional high-throughput screening in both in vitro and in vivo models identified the NB tumor-suppressive function of miR-323-5p and miR-342-5p, and indicated that the effect occurs through directly targeting CCND1, CHAF1A, INCENP, and Bcl-Xl[116]. The gene discussed is CCND1; the disease is neuroblastoma.