PTEN and neuroblastoma: Another study indicated that fluoxetine, a serotonin reuptake inhibitor, upregulated miR-572 and miR-663a consistently in NB cells and thereby inhibited their crucial targets (mir-572 - Cdkn1, Dicer1, Wnt7a; miR-663a - TGFβ1, PTEN, VEGFA) associated with NB cell differentiation and tumor evolution[165].