Pal-Bhadra and colleagues identified novel conjugate [anthranilamide-pyrazolo (1,5-α) pyrimidine] -targeted miR-34-a, mir-34-c, mir-200b, mir-107, mir-542-5p, and mir-605, which led to the up-modulation of pro-apoptotic p21, Bax, and caspases, with concomitant downregulation of pro-survival Akt, E2F1, and Bcl2 in therapy-resistant human NB cells[169]. The gene discussed is AKT1; the disease is neuroblastoma.