Loss of chromosome 1p36 region, 3p, 4p, 9p, 11q, and 14q together with gain of 1q, 2p24, 12p, 17q, and mutations of ALK and AXL receptor tyrosine kinase (AXL) and telomerase reverse transcriptase (TERT) re-arrangements may orchestrate the transformation of normal NCCs to NB cells. Here, AXL is linked to neuroblastoma.