Overall, recent studies reported the best performance of CA-125 with CA 19–9, EGFR, G-CSF, Eotaxin, IL-2R, cVCAM, MIF that improved the sensitivity with 98.2 % and sensitivity of 98.7 % in diagnosing the early stage ovarian cancer as highlighted in Table 2. This evidence concerns the gene IL2RA and ovarian cancer.