These miRNAs are involved in cell signalling pathways associated with oncogenesis, such as transforming growth factor (TGF)-β, Wnt/β-catenin, mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinases (PI3K)/AKT/mTOR pathways, which can be activated in HCC[53]. The gene discussed is AKT1; the disease is hepatocellular carcinoma.