We next employed DeepNEU to generate the unsupervised aiPSC model of infantile onset POMPE disease (IOPD) by again turning on the transcription factors OCT3/4, KLF4, SOX2, cMYC plus MyoD1 in the presence of Doxycycline, but this time the GAA gene which makes the enzyme normally responsible for lysosomal conversion of glycogen to glucose was locked off. The gene discussed is MYC; the disease is glycogen storage disease II.