In human colon cancer, IL-36γ was found in various types of cells within the tumor microenvironment such as immune cells, M1 macrophages, tumor cells, and vasculature cells including smooth muscle cells and high endothelial venules, which are associated with the maintenance of tertiary lymphoid structures (Weinstein et al., 2019). This evidence concerns the gene IL36G and malignant colon neoplasm.