In murine-induced psoriasis models, IL-36γ activates dermal DCs and macrophages and induces the production of IL-23 and TNFα, which in turn activate T cells and drive inflammation (Clark and Kupper, 2006; Stratis et al., 2006; Wang et al., 2006; Zaba et al., 2009; Fuentes-Duculan et al., 2010; Towne and Sims, 2012; Foster et al., 2014). Here, IL36G is linked to psoriasis.