As TNF-α expression has been shown to be upregulated in models of neurological disease (Colton et al., 2006; Brohawn et al., 2016; Lindenau et al., 2017), supporting the need to target TNF-α to decrease neuroinflammation accompanying neurodegeneration, the high brain penetrance of thalidomide and analogs together with an ability to repress TNF-α at the level of its synthesis, provides a promising approach to mitigate neuroinflammation. Here, TNF is linked to nervous system disorder.