Finally, in a recent study, both 3,6′DT and thalidomide were demonstrated to mitigate the severity of L-dopa-induced dyskinesia in nigrostriatal-lesioned rat models of PD, suppressing both microgliosis and elevated TNF-α in the striatum and substantia nigra, and restoring IL-10 anti-inflammatory cytokine levels (Boi et al., 2019). The gene discussed is TNF; the disease is Parkinson disease.