TNF-α inhibitors have been shown to block neurotoxin-induced nigral DA neuron loss by 50% (Mccoy et al., 2006) and attenuate reductions in striatal dopamine in MPTP rodent models (Boireau et al., 1997; Ferger et al., 2004), highlighting the potential use of these agents as treatments for PD. The gene discussed is TNF; the disease is Parkinson disease.