In the context of multiple myeloma, thalidomide analogs cause cereblon to interact with associated factors to form a ligase that breaks down Ikaros (IKZF1) and Aiolos (IKZF3), two members of the Ikaros family of zinc finger transcription factors important in B-cell development (Krönke et al., 2014). Here, IKZF3 is linked to AL amyloidosis.