Furthermore, Izzi et al. performed a comprehensive array of macrophage function tests to show that co-culture of THP-1-derived macrophages with a single mesothelioma cell line resulted in reduced phagocytic activity, increased IL-10 production, increased collagenolytic activity for tissue remodeling, and increased arachidonic acid and prostaglandin E2 production (78). This evidence concerns the gene IL10 and mesothelioma.