In addition, it was discovered that there are many kinds of 5-HTR subtypes on a variety of cancers, including PC (32), HCC (33–35), CRC (36) etc. 5-HT could promote the development and progression of these cancers by activating the 5-HTR subtypes, such as 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B (44, 99). This evidence concerns the gene HTR2B and pachyonychia congenita.