Such as DDAH1 (28), silencing of Notch4 (29), knockdown of KIAA1199 (30), knockdown of UBE2C (31), inhibition of AURKA (32), VGLL4 (33), inhibition of PRRX1 by XAV939 (34), and SOX10 (35) can inhibit invasion and EMT by suppressing the Wnt/β-catenin pathway in GC. The gene discussed is NOTCH4; the disease is gastric cancer.