On the other hand, FXYD5/Dys overexpression in Hec1a cells resulted in increased cell migration and decreased cell adhesive capacity; at the molecular level, these changes were associated with a decreased E-cadherin expression, accompanied by increased mRNA levels of Snail, Slug, and ZEB1, in agreement with previous reports in tumor samples (6, 36). This evidence concerns the gene FXYD5 and neoplasm.