CD8A and neoplasm: Form the Figure 4, we can see that several highly positive relationship among LM22 immune cells in the HNC paired adjacent tumor samples were found, while mutual relationship among LM22 immune cells reduced in the tumor samples, such as Macrophages M2 was highly positive associated with Monocytes in the immune phenotype profiles in the TMC form the HNC paired adjacent tumor samples, while T cells regulatory (Tregs) was highly negatively related to T cells CD8 in the HNC tumor group.