Based on the insulin-dependent impact of a mitochondrial uncoupler to slow obesity-associated colon cancer growth in mouse models [35], we hypothesized that the SGLT2 inhibitor dapagliflozin, which lowers both fasting and postprandial glucose and insulin concentrations, may slow obesity-associated breast and colon tumor growth through an insulin-dependent mechanism. This evidence concerns the gene SLC5A2 and colonic neoplasm.