Although tumor DNP concentrations in six CRMP-treated mouse tumors were negligible (0.015 ± 0.003 nmol/g, approximately equivalent to 0.015 μM), we confirmed that DNP did not affect tumor glucose metabolism or growth directly by measuring the rate of glucose uptake, VPDH/VCS, and cell division in vitro in MC38 cells and found each parameter to be unaltered after incubation in 1 μM DNP but increased with high concentrations of insulin (Fig. 4a–c). Here, INS is linked to neoplasm.