However, despite this excessive skepticism toward RNAi therapy, in August 2018 a small interfering RNA (siRNA) against transthyretin (TTR) mRNA, ONPATTRO (patisiran) was proven to be an effective therapy for hereditary transthyretin amyloidosis (hATTR) and approved as the first RNAi drug by both the US Food and Drug Administration (FDA) and the European Medicine Agency (EMA) [23–25]. The gene discussed is TTR; the disease is prealbumin measurement.