The CCP formed between LC and IPF is regulated by NF1, a Ras‐GTPase activating protein, which function as negative regulators for Ras proteins (Ballester et al., 1990), preventing the downstream activation of Ras effector pathways, MAPK and PI3K/Akt/mTOR pathways that drive the pro-proliferation, survival, differentiation (Xu et al., 1990; Bollag and McCormick, 1991), cell adhesion, and migration (Kweh et al., 2009). This evidence concerns the gene AKT1 and idiopathic pulmonary fibrosis.