E2F1 and cancer: The heatmap and corrplot show The coexpression network created with the 45 DEGs associated with cancer in DAVIDs enrichment analysis and the 45 TFs identified with Opossum as their possible regulators, has 35 DEGs coexpressed with four TFs (YY1, ZEB1, E2F1, and NR4A2) (Figure 5) (Shannon et al., 2003).