IRF1 is downregulated in lung cancer, IPF and PAH datasets, probably because it represses the expression of genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 (Armstrong et al., 2012) and in immune response, such as FOXP3, IL4, ANXA2 and TLR4 (Fragale et al., 2014). This evidence concerns the gene ANXA2 and pulmonary arterial hypertension.