ACTG1 and cancer: Lastly, pan-cancer analysis of dependency score (Meyers et al., 2017; Tsherniak et al., 2017) showed that CCT6A, UTP18, YRDC, RRP12, RFT1, NLE1, as well as DDOST were essential across pan-cancer including COAD cells, while ACTG1 or RHOQ were less essential in cancer cells, which indicated that the essential genes would be developed into anticancer drugs as potential targets.