A total of 12 upregulated and one downregulated genes were found to overlap with prognostic and fitness genes (Figure 3G), in which four upregulated genes (TUBA1C, ABCE1, UBE2N, and NIFK) had been reported to play roles in tumor growth, cell cycle, migration, metastasis, and prognosis (Supplementary Table 5). Here, NIFK is linked to neoplasm.