NLE1 and colon adenocarcinoma: Expression of the eight upregulated genes (YRDC, CCT6A, ACTG1, DDOST, UTP18, RRP12, NLE1, as well as RFT1) increased significantly in COAD and its subtypes (Figures 4A–H) and the expression of RHOQ decreased significantly in COAD and its subtypes (Figure 5).