Whereas FGF counteracts HH/GLI-dependent proliferation and growth of medulloblastoma (Fogarty et al., 2007b; Emmenegger et al., 2013), EGF is essential in determination of the oncogenic phenotype of HH/GLI-driven BCC (Schnidar et al., 2009; Eberl et al., 2012). Here, EGF is linked to skin basal cell carcinoma.