However, in mice, inhalation of another air pollutant, PM2.5, also causes inflammation with adipose tissue and liver, and leads to insulin resistance but the insulin resistance is not attenuated when the hepatic and adipose tissue inflammation are ameliorated by genetic deficiency in CCR2, the receptor for the macrophage chemotactic cytokines, CCL2 (42). Here, CCR2 is linked to Insulin resistance.