For instance, the dsDNA sensor IFI16, which activates IFN-β responses and forms an inflammasome, is degraded in HSV-1 infected cells by ICP0 proteasomal targeting (48) and in cells with lytic Kaposi's Sarcoma-Associated Herpesvirus infection (25). The gene discussed is IFI16; the disease is Herpesviridae infectious disease.