Accordingly, several cellular responses to autoantibody binding in pemphigus have been attributed to different signaling pathways among which are mitogen-activated protein kinases (MAPKs) such as p38MAPK and extracellular signal-regulated kinases (ERK1/2), as well as Rho GTPase, epidermal growth factor receptor (EGFR), Rous sarcoma-related kinase (Src) and protein kinase C (PKC) (12, 13). Here, EGFR is linked to pemphigus.