CLEC1B and Sepsis: It has been reported that the absence of CLEC2 increases clinical severity in a cecal ligation and puncture (CLP) model of sepsis following injection of bacterial lipopolysaccharides (47), and deletion of CLEC2 in this model exacerbates cytokine storm and inhibits inflammatory macrophage recruitment to the infected peritoneum, resulting in increased bacterial load and organ injury (47).