Taking into consideration the abovementioned data and combining them with our findings as described in Figure 4, we can speculate that oxidative stress in salivary glands of patients with SjS leads to an upregulation of ICAM-1 and PD-L1 through the implication of a ROS/JAK(1/)2/STAT3 pathway, which acts synergistically with IFN/JAK/STAT-mediated effect on ICAM-1 and PD-L1 expression, initiating in this manner the adhesion and infiltration of activated T cells. This evidence concerns the gene CD274 and Schwartz-Jampel syndrome.