Studies on SGECs have shown upregulation of both ICAM-1 and PD-L1 in SjS patients (12–14, 17, 18), and until recently, their expression was related to type I and type II IFN signaling through the implication of the JAK-STAT pathway (22–24, 27, 28). This evidence concerns the gene CD274 and Schwartz-Jampel syndrome.