SESN2 was upregulated in primary rat cortical neurons treated with amyloid-β/Aβ (a hallmark of AD-caused cytotoxicity and neuronal death) both in vitro and in vivo, and that elimination of SESN2 exacerbated Aβ-induced neurotoxicity, which indicated that SESN2 upregulation by Aβ positively modulated autophagy to protect against neurotoxicity (26). This evidence concerns the gene SESN2 and Alzheimer disease.