SESN2 and Parkinson disease: Hou et al. (84) reported that in a rotenone-induced Parkinson's disease model, the mRNA and protein levels of SESN2 were significantly upregulated in a p53-dependent manner and that silencing of SESN2 suppressed autophagy while increasing the accumulation of autophagy substrates, which manifested as downregulation of light chain 3II (LC3II), exacerbation of p62 accumulation, and inhibition of AMPK phosphorylation.