Arid5a is induced by the cytokines IL-6 and IL-17, and because IL-6 is a strong inducer of Arid5a, it is likely that IL-6-deficient mice have insufficient activation of Arid5a, which results in unrestricted adipogenesis and obesity. The gene discussed is ARID5A; the disease is obesity due to melanocortin 4 receptor deficiency.