An assessment of adolescents with T1DM who were treated with either basal-bolus or pre-mixed insulin and who attempted to fast during Ramadan reported that 61.5% of those on basal-bolus and 44% on pre-mixed insulin broke fasting due to hypoglycemia, whereas 7.6% on basal-bolus and 55% on pre-mixed insulin broke fasting due to significant hyperglycemia (16). The gene discussed is INS; the disease is Hyperglycemia.