In our study, the MMPs expression was higher in T2D– patients with obesity, and such results are consistent with the study of Kosmala et al., who observed increased MMP-2 and MMP-9 activity in obese non-diabetic patients; herewith such processes were not observed in obese diabetic patients (28). The gene discussed is MMP2; the disease is obesity due to melanocortin 4 receptor deficiency.